I’ve been in the fitness industry for over 25 years and perhaps the most fascinating fat loss drug to ever catch my eye has been Cardarine (GW501516).
You may have heard from an endurance or CrossFit buddy about this drug, but with all the poor information out there you were being told myths. This profile will separate the fact from fiction so you can take advantage of this amazing compound in your fitness arsenal.
Cardarine (GW-501516) first was developed in the early 1990’s by Ligand and GlaxoSmithKline as an anti-tumor drug. They also found out it worked well for lipid/heart health during the early trials and then how effective it was for endurance, diabetes, and getting rid of fat. It is not known why the drug was abandoned but that did not stop athletes from using it to dope, and today it is one of the most popular performance-enhancing drugs being sold to those in fitness.
Trained mice increased their exhaustive running distance by 744.4 m (31.2%) after 3 weeks of GW501516 treatment (TG versus TN) (Fig. 1a). GW501516 treatment for 3 weeks in sedentary KM mice also significantly enhanced running distance by 750.3 m (68.6%) compared to untrained control mice (p < 0.01 for NG versus NN). Similarly, even GW501516 treatment alone (NG group) for only 1 week improved the running distance by 671.8 m (48.6%) compared to the vehicle control group (NN group)
You probably have a gym buddy who raves about how Cardarine (GW 501516) helped him with endurance. Most of us hate long distance cardio, but we feel great after. This drug helps a lot with that and has been adopted as the standard in endurance sports.
It is not known who leaked Cardarine (GW-501516) to athletes, or when they started using it. It could have been as early as the mid 90’s. All we know for certain is that word spreads fast and by the 2008 Chinese Olympics, a large percentage of athletes were using it to dope, with great success. The next year it was banned by just about all doping commissions, but many athletes still take the risk and use it anyway because it is so effective.
How does it work?
Cardarine (GW 501516) is NOT a SARM (selective androgen receptor modulator). Rather it is a Peroxisome proliferator-activated receptor beta (PPAR) agonist which binds to those receptors. This means the activity in the gene is changed, causing a shift in how energy is put out. This translates into an ability to push harder and longer when it comes to endurance, without becoming winded. This can help you not just with cardio/running, but also in the weight room since you can push out another repetition and workout for longer without becoming tired.
Keep in mind this mode of action is not like taking a stimulant which sharply increases your heart rate and actually causes you to get winded faster. Cardarine (GW501516) does the opposite, you are able to rev up the engine more, without spiking your heart rate.
The benefits go beyond athletics too.
Type 2 diabetes
There is evidence that Cardarine (GW-501516) can help reverse type 2 diabetes in conjunction with a better diet lifestyle. It also helps with cholesterol.
These past few years, it has been demonstrated that treatment with PPARδ agonists normalizes blood lipids, reduces insulin resistance and adiposity in rodent and primate. Utilization of both cellular and animal models revealed that the nuclear receptor plays a central role in the control of fatty acid burning in adipose tissue and skeletal muscle.
Another big thing I want to touch on also is fat loss. Whether you are lean already, average size, or flat out obese, you can use Cardarine (GW 501516) safely to help burn away fat. Again it works very different from stimulant based fat burners. Instead, the way it works is by altering how the body reacts to the food you eat because it spikes glucose intake. This means even users who eat poorly can still lose body fat on it, however, the studies do show the better you eat and the more you exercise the sharper your results. In the end, it makes it much easier to lose fat no matter your diet.
Here we report that mRNA expression of PPARδ was increased in the skeletal muscle from exercise responders, which may provide a mechanism for the positive changes in the lipid profile and insulin sensitivity in this group. PPARδ functions as a lipid sensor that coordinates changes in gene expression to promote oxidative metabolism in skeletal muscle…PPARδ agonists mimic an exercise response by promoting gene regulatory responses in cultured human skeletal muscle.
Cardarine (GW501516) is not a hormone, it doesn’t cause heart strain, and it doesn’t aromatize into estrogen. Human studies have shown no issues when used even up to 6 months straight.
Best ways to use
Cardarine (GW-501516) can be used by itself. I recommend using 10-20mgs a day with some users choosing to dose it about 2-3 hours prior to their exercise. Expect a major boost to your endurance with users reporting a 30-45 second improvement on their 5K runs within 2 weeks of starting the compound. Fat loss benefits have been reported by users after 4-5 weeks using the drug.
During a steroid cycle:
Trenbolone is notorious for destroying endurance due to its inflammatory nature. In fact, all anabolic steroids increase inflammation in the body and can cause a loss of endurance. Due to this factor experienced anabolic users have found that stacking in 20mgs a day of Cardarine (GW 501516) will result in a stark difference in how winded they become during a workout.
During a SARM’s cycle:
I believe that using Cardarine (GW501516) as your base in a SARM cycle is a wise choice. The reason is it will boost endurance and increase fat loss, both things everyone wants, without increasing side effects. I recommend 10-20mgs a day.
During post cycle:
You can also use this drug during your post cycle therapy because it is completely nonhormonal. It will help prevent any sort of fat rebound while your body is most vulnerable. It also will keep you motivated to workout. I recommend 10-20mgs a day.
Duration of use
Although it has been found to be safe in human trials for up to 6 months, remember Cardarine (GW-501516) is still a drug and should be respected. I recommend using for up to 12 weeks only, and cycling off 4-6 weeks. After you come off you can come back on for 12 more weeks and so on.
Half-life and detection
The half-life is 24 hours so once a day dosing is adequate. As far as detection times it is unclear how long it will show up in a doping test, the assumption is up to 1 month. However, keep in mind cheating in sports is wrong and gives you an unfair advantage over your opponents. I am against doping and you will get caught eventually.
Where to buy Cardarine
It is important to realize that most Cardarine (GW 501516) is really a prohormone or clenbuterol. This is because the real drug is very difficult to source so companies try and cheat consumers. Where you get this drug is crucial, trust only approved sources. See our forums at evolutionary.org and elitefitness.com to find a legitimate source.